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Drug: Aspirin

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Are we successfully managing cardiovascular disease in people living with HIV?
Purpose of review: The aim of this study was to discuss the most recent research in the management of cardiovascular disease (CVD) in people living with HIV (PLWHIV) with a focus on screening, primary and secondary prevention. Recent findings: The cause of CVD in PLWHIV is complex and multifactorial and creates a demand for a multifaceted approach to screening and prevention. Current screening and management of CVD risk factors in PLWHIV is suboptimal, reasons for this are not clear and the data are still scarce both in the primary and secondary preventive setting. There are no optimal routine risk screening tools availab...
Source: Current Opinion in HIV and AIDS - October 7, 2017 Category: Infectious Diseases Tags: CARDIOVASCULAR DISEASE IN HIV INFECTED PERSONS: Edited by Franck Boccara and Cameron J. Holloway Source Type: research

Atorvastatin vs Aspirin in People With HIV Atorvastatin vs Aspirin in People With HIV
Which of these two drugs are better at reducing HIV-associated inflammation, and in turn, the risk for cardiovascular disease?AIDS
Source: Medscape Hiv-Aids Headlines - September 21, 2023 Category: Infectious Diseases Tags: HIV/AIDS Journal Article Source Type: news

Kawasaki-like disease (KLD) in an adult with congenital HIV infection
Conclusion It is a challenging task to diagnose Kawasaki-like disease in HIV infected adults due to a high likelihood of opportunistic infections or possible hypersensitivity to any one of the plethora of prescribed medications. A high suspicion of KLD is advised in HIV infected adults with severe immunosuppression and unexplained fever lasting>5 days to ensure timely diagnosis and treatment.
Source: HIV and AIDS Review - December 13, 2015 Category: Infectious Diseases Source Type: research

Effect of aspirin on HIV disease progression among HIV-infected individuals initiating antiretroviral therapy: study protocol for a randomised controlled trial
We present a protocol for a larger ongoing randomised placebo controlled trial on the effect of an addition of ASA to ARV drugs on HIV disease progression. Methods and analysis A single-centre phase IIA double-blind, parallel-group randomised controlled trial intends to recruit 454 consenting ARV drug-naïve, HIV-infected adults initiating ART. Participants are randomised in blocks of 10 in a 1:1 ratio to receive, in addition to ARV drugs, 75 mg ASA or placebo for 6 months. The primary outcome is the proportion of participants attaining HVL of <50 copies/mL by 8, 12 and 24 weeks. Secondary outcomes include propo...
Source: BMJ Open - November 2, 2021 Category: General Medicine Authors: Mwakyandile, T., Shayo, G., Mugusi, S., Sunguya, B., Sasi, P., Moshiro, C., Mugusi, F., Lyamuya, E. Tags: Open access HIV/AIDS Source Type: research

Extended-Release Niacin Versus Fenofibrate in HIV-Infected Participants With Low High-Density Lipoprotein Cholesterol: Effects on Endothelial Function, Lipoproteins, and Inflammation
Conclusions. Despite improvements in lipids, niacin or fenofibrate treatment for 24 weeks did not improve endothelial function or inflammatory markers in participants with well-controlled HIV infection and low HDL-C. Clinical Trials Registration. NCT01426438.
Source: Clinical Infectious Diseases - August 10, 2015 Category: Infectious Diseases Authors: Dube, M. P., Komarow, L., Fichtenbaum, C. J., Cadden, J. J., Overton, E. T., Hodis, H. N., Currier, J. S., Stein, J. H., for the AIDS Clinical Trials Group A5293 Study Team Tags: HIV/AIDS Source Type: research

Role of Prostaglandin F2{alpha} Production in Lipid Bodies From Leishmania infantum chagasi: Insights on Virulence
We report herein that LBs increased in abundance during development of Leishmania infantum chagasi to a virulent metacyclic stage, as did the expression of PGF2α synthase (PGFS). The amount of parasite LBs and PGF2α were modulated by exogenous arachidonic acid. During macrophage infection, LBs were restricted to parasites inside the parasitophorous vacuoles (PV). We detected PGF2α receptor (FP) on the Leishmania PV surface. The blockage of FP with AL8810, a selective antagonist, hampered Leishmania infection, whereas the irreversible inhibition of cyclooxygenase with aspirin increased the parasite burden....
Source: The Journal of Infectious Diseases - November 22, 2014 Category: Infectious Diseases Authors: Araujo-Santos, T., Rodriguez, N. E., Moura-Pontes, S., Dixt, U. G., Abanades, D. R., Bozza, P. T., Wilson, M. E., Borges, V. M. Tags: PARASITES Source Type: research

Safety, activity, and long-term outcomes of pomalidomide in the treatment of Kaposi sarcoma among individuals with or without HIV infection
CONCLUSIONS: Pomalidomide is a safe and active chemotherapy-sparing agent for the treatment of KS among individuals with or without HIV.PMID:34862247 | DOI:10.1158/1078-0432.CCR-21-3364
Source: Clinical Cancer Research - December 4, 2021 Category: Cancer & Oncology Authors: Ramya Ramaswami Mark N Polizzotto Kathryn Lurain Kathleen M Wyvill Anaida Widell Jomy George Priscila Goncalves Seth M Steinberg Denise Whitby Thomas S Uldrick Robert Yarchoan Source Type: research

Altered Lipidome Composition Is Related to Markers of Monocyte and Immune Activation in Antiretroviral Therapy Treated Human Immunodeficiency Virus (HIV) Infection and in Uninfected Persons
Conclusions: The lipidome is altered in ART-treated HIV infection, and may contribute to inflammation and CVD progression. Detailed lipidomic analyses may better assess CVD risk in both HIV+ and HIV– individuals than does traditional lipid profiling. Introduction Both HIV infection and the use of antiretroviral therapy (ART) contribute to an increased risk for cardiovascular disease (CVD) (1, 2). Dyslipidemia is observed in HIV-infected (HIV+) individuals, and is associated with reduced levels of high-density lipoprotein (HDL) cholesterol, and elevated total (TC) cholesterol, low-density lipoprotein (...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Predicting and preventing cardiovascular disease in HIV-infected patients.
This article summarizes a presentation by Wendy S. Post, MD, at the 14th Annual Clinical Conference for the Ryan White HIV/AIDS Program held in Tampa, Florida, in June 2011. Dr Kerunne Ketlogetswe provided additional editing. The Clinical Conference is sponsored by the IAS-USA under the Health Resources and Services Administration (HRSA) contract number HHSH250200900010C. PMID: 22298885 [PubMed - indexed for MEDLINE]
Source: Topics in antiviral medicine - November 12, 2014 Category: Infectious Diseases Tags: Top Antivir Med Source Type: research

HIV-positive adults are under-treated for cardiovascular problems compared to those without HIV
This study provides evidence that U.S. policymakers and professional societies should focus on improving the quality of the cardiovascular care that people who are HIV-positive receive.AUTHORSStudy authors are Dr. Joseph Ladapo, Dr. Adam Richards, Cassandra DeWitt, Nina Harawa, Steven Shoptaw, Dr. William Cunningham and Dr. John Mafi, all of UCLA. Mafi is also associated with Rand Corporation.JOURNALThestudy is published in the Journal of the American Heart Association.FUNDINGGrants from the National Heart, Lung and Blood Institute, National Institute on Minority Health and Health Disparities, and National Institute of Men...
Source: UCLA Newsroom: Health Sciences - November 22, 2017 Category: Universities & Medical Training Source Type: news

Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility.
Authors: Cromarty R, Archary D Abstract The relationship between inflammation and HIV has been a focus of research over the last decade. In HIV-infected individuals, increased HIV-associated immune activation significantly correlated to disease progression. While genital inflammation (GI) has been shown to significantly increase the risk of HIV acquisition and transmission, immune correlates for reduced risk remain limited. In certain HIV-exposed seronegative individuals, an immune quiescent phenotype characterized reduced risk. Immune quiescence is defined by specific, targeted, highly regulated immune responses t...
Source: AIDS Research and Treatment - November 14, 2020 Category: Infectious Diseases Tags: AIDS Res Treat Source Type: research